Diclazepam (Ro5-3448), also known as chlorodiazepam and 2′-chloro-diazepam, is a benzodiazepine and functional analog of diazepam. It was first synthesized by Leo Sternbach and his team at Hoffman-La Roche in 1960. It is not currently approved for use as a medication. But rather sold as an unscheduled substance. Also, In animal models, its effects are similar to diazepam, possessing long-acting; anxiolytic:
- sedative, s
- skeletal muscle relaxant, and
- amnestic properties.
Metabolism of this compound has been assessed, revealing diclazepam has an approximate elimination half-life of 42 hours. Also, Other metabolites detected were:
- lorazepam and
These were detectable in urine for 19 and 11 days, respectively, indicating hydroxylation by cytochrome P450 enzymes occurring concurrently with N-demethylation.
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